微孔致孔剂对钙磷陶瓷表面类骨磷灰石形成的研究

无机材料学报

微孔致孔剂对钙磷陶瓷表面类骨磷灰石形成的研究

卢晓英¹, 江奇¹, 冉均国², 苟立²

1. 西南交通大学材料科学与工程学院, 成都 610031; 2. 四川大学无机材料系, 成都 610065

收稿日期:2003-09-11 修回日期:2003-12-08 出版日期:2004-09-20 网络出版日期:2004-09-20

Effects of Micropore Porosifer on the Formation of Bone-like Apatite in the Calcium Phosphate Ceramics

LU Xiao-Ying¹, JIANG Qi¹, RAN Jun-Guo², GOU Li²

1. School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 600031, China; 2. Department of Inorganic
Material, Sichuan University, Chengdu 610065, China

Received:2003-09-11 Revised:2003-12-08 Published:2004-09-20 Online:2004-09-20

摘要/Abstract

摘要： 钙磷陶瓷表面类骨磷灰石层的形成对瓷诱导新骨生成起非常重要的作用. 本文利用体外模拟装置首次研究了微孔致孔剂对新工艺制备的含CO₃^2-的双相HA/β-TCP多孔陶瓷表面类?骨磷灰石形成的影响. 结果表明, 该陶瓷因CO₃^2-的掺入, 导致类骨磷灰石晶体的形成时间大大缩短(从14天缩短至6天). 此外还有缺钙羟基磷灰石晶体?的生成. 并且微孔致孔剂以聚乙烯醇缩丁醛(PVB)优于硬脂酸(SA)粉末, 它更有?利于类骨磷灰石的形成. 在同时加入PVB作微孔致孔剂时, 类骨磷灰石晶体的形成情况随PVB加入量的增大而越来越好. 综合其相关性能来看, PVB的加入量以m_钙磷粉:m _致孔剂=1:0.3为宜. 微孔致孔剂的优化有利于该陶瓷材料骨诱导性的提高.

关键词: 微孔致孔剂, CO₃^2-, 钙磷陶瓷, 类骨磷灰石

Abstract: The formation of the bone-like apatite containing carbonate in the calcium phosphate ceramics is important to the growth of the new bone and the
osteoinductivity of the materials. The effect of the micropore porosifer on the formation of the bone-like apatite in carbonate-contained HA/β-TCP ceramics prepared by the new technique was discussed in detail
for the first time. The results show that the bone-like apatite can be formed in shorter time (about 6 days) in this ceramics for the carbonate
mixing into the structure of the apatite crystal. The results also show that the ceramics with the PVB micropore porosifer lead to the better
bone-like apatite formation compared with the SA micropore porosifer, and the best ratio is m_{calcium phosphate powder}:m_PVB=1:0.3.
The optimization of the micropore porosifer is good to improving the osteoinductivity of the carbonate-contained HA/β-TCP ceramics, which
is great help to the restoration of the bone defect.

Key words: micropore porosifer, carbonate, calcium phosphate ceramics, bone-like apatite

中图分类号:

R318
TQ174

卢晓英,江奇,冉均国,苟立. 微孔致孔剂对钙磷陶瓷表面类骨磷灰石形成的研究[J]. 无机材料学报.

LU Xiao-Ying,JIANG Qi,RAN Jun-Guo,GOU Li. Effects of Micropore Porosifer on the Formation of Bone-like Apatite in the Calcium Phosphate Ceramics[J]. Journal of Inorganic Materials.

[1]	俞佳,肖秀峰, 梁建鹤,刘榕芳, 王春燕,毛丹. 交替循环浸泡在TiO₂纳米管管内填充类骨磷灰石[J]. 无机材料学报, 2011, 26(1): 78-84.
[2]	吴尧,李虎,邓春林,杨帮成,张兴栋. 不同表面特征的多孔钛与皮下软组织间生物力学性质的研究[J]. 无机材料学报, 2005, 20(1): 112-118.
[3]	段友容,王朝元,陈继镛,张兴栋. 磷酸钙陶瓷在不同动物的模拟体液中类骨磷灰石的形成研究[J]. 无机材料学报, 2002, 17(6): 1239-1244.
[4]	段友容,王朝元,陈继镛,张兴栋. 致密磷酸钙陶瓷在动态SBF中类骨磷灰石层形成研究[J]. 无机材料学报, 2002, 17(3): 552-558.