蜡球造孔法制备多孔HA陶瓷支架及其性能优化

doi:10.3724/SP.J.1077.2013.12176

无机材料学报 ›› 2013, Vol. 28 ›› Issue (1): 74-78.DOI: 10.3724/SP.J.1077.2013.12176 CSTR: 32189.14.SP.J.1077.2013.12176

蜡球造孔法制备多孔HA陶瓷支架及其性能优化

赵婧¹, 李金雨², 智伟², 鲁雄², 贾治彬², 翁杰²

(西南交通大学 1. 机械工程学院; 2. 材料科学与工程学院, 材料先进技术教育部重点实验室, 成都610031)

收稿日期:2012-03-20 修回日期:2012-09-18 出版日期:2013-01-10 网络出版日期:2012-12-20
作者简介:赵婧(1982–), 女, 博士, 讲师. E-mail: jzhao@swjtu.edu.cn
基金资助:
国家重大科学研究计划(2012CB933602);国家自然科学基金(51205327, 51172188);中央高校基本科研业务费专项资金(A0920502051113-95);四川省青年科技基金创新团队项目(2010JQ0081)

Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

ZHAO Jing¹, LI Jin-Yu², ZHI Wei², LU Xiong², JIA Zhi-Bin², WENG Jie²

(1. School of Mechanial Engineering, Southwest Jiaotong University, Chengdu 610031; 2. Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031)

Received:2012-03-20 Revised:2012-09-18 Published:2013-01-10 Online:2012-12-20
About author:ZHAO Jing. E-mail: jzhao@swjtu.edu.cn
Supported by:
National Basic Research Program of China (2012CB933602);National Natural Science Foundation of China (51205327, 51172188);Fundamental Research Funds for the Central Universities (A0920502051113-95);Sichuan Science and Technology Fundation for Young Scholar Innovation Groups (2010JQ0081)

摘要/Abstract

摘要：

组织工程支架的贯通性对其体内生物学表现具有重要影响。采用甲壳素溶胶体系和蜡球造孔剂制备多孔羟基磷灰石(HA)陶瓷支架, 考查在相同模压条件下, 不同浆料/造孔剂比例对多孔HA陶瓷支架的孔隙率、收缩率、贯通性、多孔结构以及抗压强度的影响。结果表明: 该方法可以制备具有高孔隙的多孔HA陶瓷支架, 随着造孔剂比例的增大, 支架的贯通性更好, 当浆料/造孔剂比例为1:1.2时可以得到孔隙率、贯通性、力学性能最优的多孔HA陶瓷支架。

关键词: 多孔HA陶瓷支架, 蜡球堆积, 贯通性, 抗压强度

Abstract:

Interconnectivity of tissue engineering scaffolds plays a very important role in biological performance in vivo. In this work, chitin sol and wax spheres were used for preparing porous hydroxyapatite (HA) ceramics scaffolds by particle leaching and gel-casting methods. Under the same mounded casting condition, the effect of ratio of slurry/wax pore former on porosity, shrinkage, interconnectivity, porous structure and compressive strength were investigated systematically. Porous HA ceramic scaffolds were evaluated by gravimetric method, stereomicroscope, X-ray diffraction (XRD), scanning electron microscope (SEM) and universal testing machine. The results show that the present method is an effective method to fabricate a highly porous HA ceramic scaffolds. With increasing the ratio of slurry/wax spheres, the interconnectivity gets better and the optimal ratio of slurry/wax spheres is 1:1.2.

Key words: porous HA ceramic scaffolds, accumulated wax spheres, interconnectivity, compressive strength

中图分类号:

R318

赵婧, 李金雨, 智伟, 鲁雄, 贾治彬, 翁杰. 蜡球造孔法制备多孔HA陶瓷支架及其性能优化[J]. 无机材料学报, 2013, 28(1): 74-78.

ZHAO Jing, LI Jin-Yu, ZHI Wei, LU Xiong, JIA Zhi-Bin, WENG Jie. Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method[J]. Journal of Inorganic Materials, 2013, 28(1): 74-78.

图/表 8

图1 多孔HA陶瓷支架的制备工艺流程和模压过程示意图

Fig.1 (a) Flow chart of preparation process and (b) sketch map of moulding process for porous HA ceramic scaffold

图2 造孔剂蜡球的形貌

Fig. 2 Appearance of the pore former of wax spheres

图3 烧结后多孔HA陶瓷支架的XRD图谱

Fig. 3 XRD pattern of sintered porous HA scaffold

图4 不同模压下多孔支架的形貌

Fig. 4 Stereo microscope morpholegies of the porous scaffolds under different casting strengths

Table 1 Properties of porous HA ceramic scaffolds with different ratios of slurry/wax spheres

Slurry/wax spheres	Porosity/%		Shrinkage/%		Interconnected pores/μm
Slurry/wax spheres	HA-20	HA-30	HA-20	HA-30	HA-20	HA-30
1:1.0	85.5	89.0	50.3	35.6	227±91	323±72
1:1.2	85.6	90.1	50.9	35.5	277±83	346±79
1:1.4	86.8	91.4	51.8	35.3	326±93	372±95
1:1.6	87.1	91.8	52.5	35.4	390±121	404±97

图5 HA-20和HA-30支架的体式显微镜照片

Fig. 5 Stereo microscope morphologies of HA-20 (a, b) and HA-30 (c, d) scaffolds with the slurry/wax spheres ratio of 1:1 (a,c) and 1:1.6 (b,d)

图6 孔壁的典型结构

Fig. 6 SEM images of typical microstructure of pore wall

图7 不同浆料/蜡球比例的多孔HA陶瓷支架的抗压强度

Fig.7 Compressive strengths of porous HA ceramics scaffolds with different ratios of slurry/wax spheres

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蜡球造孔法制备多孔HA陶瓷支架及其性能优化

Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

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