上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展
海热古·吐逊1(
), 郭乐2, 丁嘉仪2, 周嘉琪1, 张学良1, 努尔尼沙·阿力甫1()
), 郭乐2, 丁嘉仪2, 周嘉琪1, 张学良1, 努尔尼沙·阿力甫1()
Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging
HAIREGU Tuxun1(), GUO Le2, DING Jiayi2, ZHOU Jiaqi1, ZHANG Xueliang1, NUERNISHA Alifu1()
), GUO Le2, DING Jiayi2, ZHOU Jiaqi1, ZHANG Xueliang1, NUERNISHA Alifu1()
图9. NaYF4: Yb/Er@NaGdF4@金属有机框架(MOFs)@阿霉素(DOX)的制备及其UCL/MRI应用[
Fig. 9. Preparation and UCL/MRI application of NaYF4: Yb/Er@NaGdF4@metal-organic frameworks (MOFs) @doxorubicin (DOX)[
(a) Schematic illustration of NaYF4: Yb/Er@NaGdF4@MOFs (UCMOFs) for dual pH-response drug release, UCL imaging and MRI; (b) Confocal fluorescence images of HeLa cells after incubation with NaYF4: Yb/Er@NaGdF4@MOFs@DOX (UCMOFs@D) for 2, 4 and 6 h at 37 ℃, with purple indicating released anticancer drug DOX, green and red indicating UCL (scale bar: 20 µm)
