上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展

海热古·吐逊, 郭乐, 丁嘉仪, 周嘉琪, 张学良, 努尔尼沙·阿力甫

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

HAIREGU Tuxun, GUO Le, DING Jiayi, ZHOU Jiaqi, ZHANG Xueliang, NUERNISHA Alifu

图7 含镧系元素Yb (a)和Lu (b)的UCNPs用作CT成像造影剂[56-57]

Fig. 7 UCNPs containing lanthanide elements Yb (a) and Lu (b) used as CT imaging contrast agents[56-57] (a) In vivo CT imaging after intravenous injection of 1 mL UCNPs (Yb: 70 mg·mL-1), with photos showing heart and liver, spleen and kidney, and three-dimensional CT images, respectively[56]; (b) Application of NaYF4: Nd3+@NaLuF4@PDA used for CT imaging, with photos showing X-ray images and HU values of NP@PDA18 nanocomposites and iodoxazole aqueous solution with different concentrations, and X-ray CT images of HeLa tumor bearing nude mice before and after intratumoral injection of 100 μL of NP@PDA18 solution (3 mg·mL-1)[57]