上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展

海热古·吐逊, 郭乐, 丁嘉仪, 周嘉琪, 张学良, 努尔尼沙·阿力甫

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

HAIREGU Tuxun, GUO Le, DING Jiayi, ZHOU Jiaqi, ZHANG Xueliang, NUERNISHA Alifu

图14 FYH-PDA-DOX纳米颗粒用于UCL/CT/MRI多模态成像引导的光热治疗(PTT)-化学免疫治疗[77]

Fig. 14 FYH-PDA-DOX nanoparticles used for photothermal therapy (PTT)-chemo-immunotherapy with multimodality UCL/CT/MRI guidance[77] (a) Preparation process of FYH-PDA-DOX complex; (b) Schematic illustration using FYH-PDA-DOX for PTT-chemo-immunotherapy by combining immunogenic cell death (ICD)/ immune checkpoint blockade (ICB) with UCL/CT/MRI guidance; (c) 3D rendering of CT imaging and their corresponding coronal images of mice after injection of FYH-PDA-DOX solutions at timed intervals; (d) T2-MRI of mice before and after injection of FYH-PDA-DOX solutions; (e) Fluorescence images of excised tumors and major organs