上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展

海热古·吐逊, 郭乐, 丁嘉仪, 周嘉琪, 张学良, 努尔尼沙·阿力甫

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

HAIREGU Tuxun, GUO Le, DING Jiayi, ZHOU Jiaqi, ZHANG Xueliang, NUERNISHA Alifu

图12 MUCNPs@BPNs-Ce6复合纳米颗粒在T1、T2加权MRI中的应用[72]

Fig. 12 Application of MUCNPs@BPNs-Ce6 in T1- and T2-weighted MRI[72] (a) Linear correlation between longitudinal relativities (r1) and equivalent Mn concentrations of MUCNPs@BPNs-Ce6 at pH 6, with insets showing T1-weighted MR images of MUCNPs@BPNs-Ce6 solution at various Mn concentrations; (b) Linear correlation between longitudinal relativities (r2) and equivalent Fe concentrations of MUCNPs@BPNs-Ce6, with insets showing T2-weighted MR images of MUCNPs@BPNs-Ce6 solution at various Fe concentrations; (c) Blood time activity curve for MUCNPs@BPNs-Ce6 by measuring Fe concentration; (d) In vivo MR images of the tumor of mice before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (e) T1-weighted MR signals in the tumor before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (f) Biodistribution results of HeLa tumor-bearing mice before and after injection with MUCNPs@BPNs-Ce6 in MRI for 24 h; (g) In vivo fluorescence images of HeLa tumor-bearing mice before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (h) Ex vivo fluorescence images of organs and tumor after injection with MUCNPs@BPNs-Ce6 for 24 h; (i) In vivo ultrasonic imaging of HeLa tumor-bearing mice after injection with MUCNPs@BPNs-Ce6 for different time