上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展

海热古·吐逊, 郭乐, 丁嘉仪, 周嘉琪, 张学良, 努尔尼沙·阿力甫

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

HAIREGU Tuxun, GUO Le, DING Jiayi, ZHOU Jiaqi, ZHANG Xueliang, NUERNISHA Alifu

图11 双光敏剂二氢卟吩e6(Ce6)和孟加拉玫瑰红(RB)结合形成的MOF@UCNP用于MRI/UCL双模态成像[69]

Fig. 11 MOF@UCNP formed by combination of dual photosensitizers chlorin e6 (Ce6) and rose Bengal (RB) used for MRI/UCL dual-mode imaging[69] (a) Schematic illustration of fabrication process and operation for imaging-guided photodynamic therapy (dual photosensitizers of Ce6 and RB loaded into MOF nanoparticles and further combined with NaGdF4: Yb,Er@NaGdF4: Nd/Yb via electrostatic interaction to form MOF@UCNP (denoted as CR@MUP)); (b) Fluorescence images of 4T1 tumor-bearing mice at different time after intravenous injection of CR@MUP with white circles showing the tumors; (c) T1-weighted MR images and T1 relaxation curves of CR@MUP; (d) T1-weighted MR images with white circles showing the tumors; (e) Quantification analysis of MR signals of 4T1 tumor-bearing mice treated with CR@MUP