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微纳米结构生物材料在骨组织再生修复中的研究进展
赵睿1,2(), 毛飞1, 钱晖1(), 杨晓2, 朱向东2, 张兴栋2
Micro-/Nano-structured Biomaterials for Bone Regeneration: New Progress
ZHAO Rui1,2(), MAO Fei1, QIAN Hui1(), YANG Xiao2, ZHU Xiangdong2, ZHANG Xingdong2

图5. 连续荧光标记评估动态骨形成[16]

Fig. 5. In vivo sequential fluorescence labeling of new bone formation inside porous nwHA bioceramics[16]
(a) Observed patterns of new bone formation (yellow: tetracycline label; green: calcein label); (b) Two types of osteogenesis discovered inside the pore structure of nwHA bioceramics (green indicating CD 31, Red indicating EMCN, and blue indicating nucleus); (c) Comparison of mineral apposition rate (MAR) between different nwHA groups, with statistical analysis of the relationship between osteogenesis type and pore diameter of the bioceramics, and the relationship between osteogenesis type and MAR