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铜基纳米酶的特性及其生物医学应用
牛嘉雪1(), 孙思2, 柳鹏飞1, 张晓东1,2, 穆晓宇1()
Copper-based Nanozymes: Properties and Applications in Biomedicine
NIU Jiaxue1(), SUN Si2, LIU Pengfei1, ZHANG Xiaodong1,2, MU Xiaoyu1()

图7. 铜基纳米酶在肿瘤治疗中的应用[56,106]

Fig. 7. Cu-based nanozymes for tumor therapy[56,106]
(a) Schematic illustration of Cu-Cys NPs preparation and chemodynamic therapy for tumors; (b, c) Changes in body weight (b) and tumor size (c) of MCF-7R tumor-bearing mice with different treatments; (d) Photographs of tumor in different groups after 40 d of treatment; (e) Average tumor masses excised from MCF-7R tumor-bearing mice from each group[56]; (f) Schematic illustration of the synergistic anticancer mechanism of nHACI based on PDT and PD-1 blockers; (g) Average tumor volume, (h) photographs and (i) weights of tumor in different groups; (j) Survival curves of B16F10 tumor-bearing mice in different groups[106]
GSH: Glutathione; GSSG: Oxidized glutathione; ROS: Reactive oxigen species; DOX: Doxorubicin; HHA: Hydrazided hyaluronan