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铜基纳米酶的特性及其生物医学应用
牛嘉雪1(), 孙思2, 柳鹏飞1, 张晓东1,2, 穆晓宇1()
Copper-based Nanozymes: Properties and Applications in Biomedicine
NIU Jiaxue1(), SUN Si2, LIU Pengfei1, ZHANG Xiaodong1,2, MU Xiaoyu1()

图6. 铜基纳米酶在急性肾损伤中的应用[34,86]

Fig. 6. Cu-based nanozymes for AKIg[34,86]
(a) Schematic illustration of the establishment of AKI and Cu5.4O USNPs for the treatment[86]; (b) Survival curves and the levels of (c) CRE and (d) BUN in different groups at 24 h after treatments[86]; (e, f) The levels of (e) kidney injury molecules-1 (KIM-1) and (f) heme oxygenase-1 (HO-1) in kidney of different groups[86]; (g) Schematic illustration of CTMDs in AKI induced by endotoxemia[34]; (h) Survival curves, (i) levels of oxidative stress containing lactate dehydrogenase (LDH), TNF-α, IL-6, and (j) levels of CREA and BUN[34]; (k) H&E images of different groups[34]
PBS: Phosphate buffer solution; AKI: Acute kidney injury; CRE: Creatinine; BUN: Blood urea nitrogen; LPS: Lipopolysaccharide; CTMDs: Cu-tetrakis(4-carboxyphenyl)porphyrin) MOF dots