Fig. 5. Cu-based nanozymes for wound healing[86,98] (a) Schematic illustration of the Ni4Cu2 /F127 composite hydrogel dressing in wound healing; (b) Photographs of wounds with different treatments on days 0, 1, 3, 5, and 7 with scale bar representing 5 mm; (c-f) Statistical analysis of the cross-sectional length of wound (c), epidermal thickness (d), granulation tissue thickness (e), number of blood vessels (f) around wound on day 7[98]; (g) Schematic illustration of Cu5.4O USNPs with multiple enzyme-like activities and broad-spectrum ROS scavenging abilities; (h) Photographs of diabetic wounds at different time points with a 6-mm-diameter standard green disc as the size reference; (i) Schematic illustration of Cu5.4O USNPs in diabetic wounds healing; (j) Percentage of wound closure area at different time points; (k) Representative histological images and (l) quantification for the length of regenerated epidermis on day 15 post-surgery; (m) Representative histological images and (n) quantification for the granulation tissue on day 15 post-surgery[86] ROS: Reactive oxigen species; GSH: Glutathione; GSSG: Oxidized glutathione
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