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铜基纳米酶的特性及其生物医学应用
牛嘉雪1(), 孙思2, 柳鹏飞1, 张晓东1,2, 穆晓宇1()
Copper-based Nanozymes: Properties and Applications in Biomedicine
NIU Jiaxue1(), SUN Si2, LIU Pengfei1, ZHANG Xiaodong1,2, MU Xiaoyu1()

图3. 铜基纳米酶的类氧化酶活性和产生ROS能力[69,81]

Fig. 3. Oxidase-like and ROS generating activity of Cu-based nanozymes[69,81]
(a) 1H NMR spectra of GSH at different points during reaction with SSNEs; (b, c) Kinetics of GSHOx-like (b) and POD-like (c) activities of SSNEs and SSNES-G; (d) ·OH generating activity of SSNEs and SSNES-G[69]; (e) 1O2 generating activity of Cu SAzyme with DPBF serving as the indicator; (f) 1O2, O2·- and ·OH generating activity of Cu SAzyme with TEMP, BMPO and DMPO as trapping agents in the presence of H2O2[81]
GSH: Glutathione; SSNEs: Single-site nanozyme; GSHOx: Glutathione oxidase; POD: Peroxidase; DPBF: 1,3-diphenyl isobenzofuran; mM: mmol/L; μM: μmol/L